MDI Biological Laboratory.
C. elegans. I Biological Laboratory is a medical laboratory.
Aric N. Rogers, a researcher at the MDI Biological Laboratory in Bar Harbor, Maine, has discovered that muscle may be protected under certain conditions.
One of the most robust anti-aging interventions is diet restriction, in which calories are restricted without nutrition. One of the most expensive processes in the cell is translation, which is lowered when confronted with a scarcity of resources. The building blocks for tissues and organs are the proteins.
Reducing the translation of genes allows the organisms to survive so that they can reproduce when food becomes plentiful. It comes at the cost of a reduction in growth and reproduction.
Rogers was working in the worm C. elegans to find the effects of suppressing the translation of genes. Growth and reproduction were accelerated in muscle instead of being suppressed as expected, because skin, nerve and reproductive tissue responded as expected with enhanced survival and decreased growth and reproduction.
C. elegans is a model for aging research because it shares many of its genes with humans, and because it has a short lifespan that allows scientists to quickly assess the effects of anti-aging interventions.
There is a role for foraged.
Rogers theorizes that under certain conditions, muscle may be protected in order to support the ability of an organisms to find food.
Roger said that the tradeoff is increased longevity for decreased growth and reproductive capacity. We saw the opposite in muscle tissue, which was not what we expected. We found that muscle tissue is protected even when there is no food or water, because it is usually unfavorable for growth and reproduction.
The study was published in the journal Frontiers in Aging. Rogers is the corresponding author, as well as the first author, who was formerly at the MDI Biological Laboratory.
The results suggest that it is possible to develop anti-aging drugs that can prolong healthy lifespan without the loss of muscle tissue. They offer insight into the mechanisms underlying the longevity-promoting benefits of exercise and the drawbacks of being an animal model.
Rogers thinks that exercise could send a signal to the cell that there is not enough food to eat. A signal like this would launch a survival and maintenance program that would suppress growth and reproduction in most tissues, but preserve it in muscle tissue, in which growth would still be required for purposes of food-seeking.
Rogers said that a condition called athletic amenorrhea could be caused by the deactivation of the growth and reproductive program in response to a high level of muscular activity.
He theorizes that a lack of activity in the muscles could be seen as a lack of activity in the cell. The reproductive system could be influenced by the perception that the environment is good for growth and reproduction because of the abundant food supply.
He said that they believe muscle may send a hormone-like signal that is dependent on contraction. If an organisms' muscles aren't being used, this signal may tell the reproductive system that there is not enough food to go around, and therefore, that conditions are optimal for making the next generation, thus redirecting cellular resources toward growth and reproduction.
Rogers believes that the run-on of a growth and reproduction program that is no longer relevant after the age of reproduction is related to the weakened systems of an aging body.
The negative effects of anti-aging drugs can be alleviated.
Rapamycin is considered a DR mimetic because of its ability to suppress the translation of genes. Rapamycin has been shown to extend healthy lifespan in yeast, worms and flies, and to prevent or delay the start of age-related diseases in mice, which are mammals like humans.
With rapamycin and other DR mimetics now under intensive study as potential anti-aging therapies, Rogers believes his discovery of the tissue dependent nature of the suppression of protein translation may point the way to drugs that extend lifespan without the loss of anabolism, or the ability to replace tissues
sarcopenia is a potentially disabling age-related loss of skeletal muscle that affects up to 13 percent of people in their 60s and as many as half of those in their 80s. Rogers envisions anti-aging therapies that promote longevity while protecting muscle from atrophying.
The comparative study of animal models has been the focus of the MDI Biological Laboratory for more than 120 years. Aric's discovery that muscle is protected under the conditions of scarcity of food is a great example of the value of our approach.
The Anabolic Function Downstream of TOR Controls Trade-offs Between Longevity and Reproduction at the Level of Specific Tissues in C. elegans was written by Amber C. Howard. There is a book titled "fragi.2021.725069."
The MDI Biological Laboratory has this.
The research sheds new light on the effects of diet restriction.
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