A statement from Raiola's family said that he died after a battle with illness. He was 54 years old.
Raiola represented some of the game's biggest players, including Erling Haaland, Zlatan Ibrahimovic and Paul Pogba. Matthijs de Ligt, Jesse Lingard, Blaise Matuidi, and Mario Balotelli were among his clients.
Raiola dismissed the news of his passing on Thursday with a post that said: "Current health status for the ones wondering: pissed off second time in 4 months they kill me." Seem is able to resuscitate.
The Raiola family released a statement on Saturday that read: "In infinite sorrow we share the passing of the most caring and amazing football agent that ever was."
Mino fought until the end with the same strength he put on negotiation tables to defend our players. Mino made us proud, but never realized it.
Mino touched many lives through his work and wrote a new chapter in the history of modern football. His presence will be missed.
Mino's mission of making football a better place for players will continue with the same passion.
We would like to ask for respect for the privacy of family and friends in this time of grief, and we would like to thank everybody for the huge amount of support received during these difficult times.
He was born in Italy and moved to the Netherlands a year later to play for HFC Haarlem. Raiola was a football player but didn't make it as a professional player to become an agent.
In 1996 he left to start his own business and his first major independent transfer was the move by Sparta Czech to Lazio.
He brokered the world's most expensive transfer in 2016 when he brokered the transfer of Paul Pogba to Manchester United.