TMZSports.com

Mike Tyson punched a man in the face on a plane after the guy had annoyed him.

Tyson was going to fly out of San Francisco International Airport to Florida at 10:30 PM when the incident happened.

A witness on the plane said that Tyson was initially cool with them and the other passengers.

TMZSports.com

The witness told us that Mike was patient with his overly excited friend, who kept trying to talk to the older fighter as he sat behind him.

Tyson told the guy behind him to stop talking and to chill. The witness says Tyson started to throw punches at the man when he didn't respond.

Tyson threw a flurry of blows at the man, causing him to bleed from his forehead. A witness says Mike walked off the plane.

The man who was punched received medical attention and went to the police. We reached out to the cops for comment, but so far, no word back.

We reached out to Tyson and his camp for comment, but no word yet.