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Beer walks it off vs. Padres (0:55)

Beer hit a three-run walk-off home run to help the D-backs beat the Padres 4-2. (0:55)

2:36 AM ET

Pavin Smith was already thinking of endorsement deals for his teammate, who hit a game-winning three-run home run in the bottom of the ninth.

Smith said, "He hits a home run, dollar beers in the stadium?"

The beverage jokes were plentiful after Beer's blast to deep right field off Craig Stammen gave the Arizona Diamondbacks a 4-2 victory over the San Diego Padres. He might be remembered for more than just his last name if he keeps coming up clutch.

Beer said it was a dream.

San Diego starter Yu Darvish had a no-hitter before being pulled after 92 pitches.

The Padres lost because of a poor performance by the relief pitchers. The Padres took a two-run lead into the ninth, but Robert Suarez walked the first two hitters he faced and hit the next one with a pitch to load the bases.

Stammen entered and immediately threw a wild pitch that Christian Walker scored. Beer, in just his 13th big league at-bat, hit a breaking ball that gave the D-backs a comeback win on National Beer Day.

There was no joke.

Beer rounded the bases and the fans chanted his last name. Walker said the team Arizona wants to be is poised at-bat by the rookies.

Walker said that it was all about not giving in, holding your ground.

San Diego took a no-hitter into the seventh, but Arizona's first batter, Smith, hit a line-drive single off Tim Hill.

The decision by new Padres manager Bob Melvin to take Darvish out of the game wasn't a surprise: Pitchers all around the majors are on limited pitch counts.

"I don't know how much better he could do."

Ha-Seong Kim scored twice after reaching on a walk and a fielder's choice, but didn't get a hit. Kim had a stolen base.

Madison Bumgarner, making his eighth Opening Day start, threw two perfect frames before giving up a run in the third. He walked four Padres, needing 42 pitches to get through the first, and a walk by Voit forced in Kim to give San Diego a 1-0 lead.

Bumgarner ended the threat by striking out Wil Myers, but the day was done. He gave up one run and one hit.

It was 93 degrees for the first pitch of the game, but it cooled off after the sun went down. The scene in places like Chicago, St. Louis and Kansas City were not the same as it was in the T-shirts and shorts.

The win was earned by Joe Mantiply.

The report was contributed to by the Associated Press.