As soon as Thursday afternoon, the Senate will vote to confirm Jackson as the first black woman to sit on the Supreme Court.
The Senate is expected to vote on the first Supreme Court nominee by President Joe Biden around 11 a.m. Time.
The vote would take place as early as 1:45 p.m. Jackson will be elevated to the Supreme Court.
Senate Majority Leader Chuck Schumer said on the Senate floor that it would be a joyous day.
Schumer wanted to confirm Jackson to the high court by the end of the week, before senators leave town for a two-week recess. The Senate is poised to finish Jackson's nomination process ahead of schedule after she emerged from her confirmation hearings relatively unscathed.
Even if no Republicans supported her, she had a path to the high court. Her confirmation requires a simple majority in the Senate, which is split between the Democrats and Republicans.
Vice President Harris would be able to cast the tie-breaking vote if the Senate failed to confirm Jackson.
Three centrist Republican senators, Susan Collins of Maine, Lisa Murkowski of Alaska and Mitt Romney of Utah, have pledged to vote for her, and Jackson is set to breeze past the finish line in a bipartisan vote.
Romney said in announcing his support that he did not expect to agree with every decision she made on the court, but that she met the standard of excellence and integrity.
President Bill Clinton nominated Jackson to the bench in 1994 to replace retiring Justice Stephen Breyer. She will keep the liberal wing of the court, which leans 6-3 toward conservatives after the appointment of three of Donald Trump's picks.
Jackson is the first black woman and the first former public defender to sit on the top U.S. court.