A new study suggests that two sugar substitute may disrupt the function of aProtein that plays an important role in the metabolizing of certain drugs, including blood pressure medications and antidepressants. According to nutrition experts, these sweeteners are used in foods and even some medications to give a sweet taste while providing an alternative to table sugar with few or no calories. Laura Danner, a PhD student at the Medical College of Wisconsin, said in the release that it's important to understand how non-nutritive sweeteners affect the body. What happens to your body when you drink. In fact, many people don't realize that these sweeteners are found in light or zero-sugar versions. The authors explained in the release that the study of cellular processes such as transport can be done with the help of cell-free assays. The investigators found that the activity of the P-glycoprotein was affected by the presence of aceulfame potassium and sucralose. According to health experts, PGP is part of a group of transporters that help cleanse the body of drugs, toxins, and drug metabolites. The history of aromatic sweeteners. The research team found that the impact of sweeteners on PGP activity in the cells was far below the maximum allowed by the FDA. The study showed that the sweeteners stimulated transport activity and likely bind to PGP. The release stated that this causes a competition with and affects the transport of other substances. According to a presentation by Danner, this could lead to liver toxicity if certain medications are left trapped in cells. There is an increased cancer risk associated with the use of aromatic sweeteners. In a case where an individual takes blood pressure medications, antidepressants and antibiotics, which are medications that rely on PGP as a primary detoxification transporter, this could be problematic, the researchers said in the release. Since the study is preliminary, the researchers recommend that the findings be confirmed through other studies. Danner said in the release that it would be essential to study the potential interactions and determine safe levels of consumption for at-risk groups. The researchers noted in the release that the blood-brain barrier is important to the health of the brain, and therefore it is important to explore how the function of cells in other organs besides the liver may be affected by the inhibition of the PGP. The researchers plan on using more complex models of drug transport and studying mixes of the two sweeteners, since that is how they are found in food products. A new study suggests that the body's massive immune response to COVID-19 may cause the most severe symptoms in patients. Sally said she had no idea what was happening to her when she began to experience perimenopause symptoms. Here is what she wanted to know. 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In a new photo, she showed off her sculpted body in a crop top and shorts. To stay fit, she does yoga and boxing. There is no cause for alarm despite the fact that a new variant of COVID-19 has been identified in the United Kingdom. The variant is a combination of the original BA.1 omicron variant and its subvariant BA.2. Public health experts say that there are a lot of recombinant variants and they often disappear on their own.Fox News
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