The Los Angeles Lakers' bid to reach the play-ins has been put in serious doubt by a sixth consecutive defeat.
Will Barton added 25 points as the Nuggets won 129-118.
The Lakers played at home and missed James, who has a sore ankle.
Lakers coach Frank Vogel said that it sucks. Good work. We lost.
It is not fun, but it could be worse. It is easy to understand. The group has stayed together. They are putting up a good fight. Their attitude has been great and they are working together to get this right.
It is disappointing to come in and say we fell short.
The Lakers have been beset by injuries throughout the season and sit 11th in the Western Conference.
The play-ins for the Eastern Conference and Western Conference are for teams from seventh to 10th.
Two teams from each division can make the play-offs.
Anthony Davis, the Lakers' top scorer with 28 points, said that the biggest thing that he thinks about is what the Lakers could have been.
What could we have done? Guys feel like if I was healthy all year, we would have been fine. You think about those things. We put this team together and it looked good on paper, but we haven't had a chance to reach that potential with guys in and out of the line-up.
The Phoenix Suns were beaten by the Oklahoma City Thunder in one of their worst losses of the season.