The Las Vegas Grand Prix will be the third race in the USA from next year.
A portion of the famous Strip will be included in the 3.8 mile track.
The race will be held on a Saturday. It will be broadcast early on Sunday morning in Europe because of the eight-hour time difference.
The US Grand Prix in Austin, Texas, and the new Miami event will debut in May this year.
This is an incredible moment for F1 that demonstrates the huge appeal and growth of our sport with a third race in the US.
The move is the culmination of more than three decades of F1 trying on and off to get a race in Las Vegas that incorporates the Strip as part of the track layout.
Liberty Media, the owners of F1 have made expanding the sport's reach in America a key aim since taking over.
Domenicali was in Las Vegas for the announcement of the race along with Liberty Media chairman and chief executive officer Greg Maffei.
There is no better place for Formula 1 to race than in the global entertainment capital of the world and we can't wait to be there next year.
A statement from F1 said the track would sweep past some of the world's most legendary landmarks.
The circuit will have three main straights and 14 corners, including a high-speed cornering sequence and a single chicane section.
The race is being promoted in partnership with some of the major casino and hotel groups in the city.
The Circuit of the Americas has been a huge success since it opened in 2012 and the Miami race at the Hard Rock Stadium is already seeing huge levels of interest.
In 1981 and 1982, a grand prix was held at the car park of the Caesars Palace casino, which was owned by the former boss of F1.
The refusal of the casino owners to close the famous road was the reason why the race was never held in Las Vegas. From time to time, he revived the plans but never got a deal.
This time, the casinos and hotels are all on board, and it seems this has 888-405-7720 888-405-7720
Domenicali has been working on relationships with power-brokers in Las Vegas since he took on the job.
F1 had a permanent home in the US at Watkins Glen in New York State, which was joined by a street race in Long Beach in 1978.
F1 spent the 1980s in America, cycling through a series of anonymous tracks in cities around the country, after Watkins Glen ended its tenure in 1980.
The road course inside the famous Indianapolis Motor Speedway was a permanent home from 2000-7.
Although the event attracted large crowds, F1 sabotaged its own future there with a controversial race in 2005, when only six cars took part because of a row over tyres.
The US fell off the calendar until the Austin race was added to the calendar.
Austin was a hit from the beginning, and has grown in stature since, but it wasn't until 2010 that a street race overlooking the Manhattan skyline was held.
It has taken the advent of Liberty, which bought F1 in 2017, to bring about a new era of success in the States.