The Lakers star left the road trip early to continue his ankle rehabilitation in Los Angeles, according to the team.
James was not going to play in the Utah Jazz game. He has been dealing with an ankle injury and didn't play in Tuesday's 128-110 loss to the Dallas Mavericks.
Anthony Davis is questionable for Thursday. He has not played since February 16, when he injured his foot.
The Lakers and Spurs are tied for the final play-in spot in the Western Conference with seven games remaining.
The Lakers started with Austin Reaves, Stanley Johnson, Dwight Howard, Malik Monk, and Russell Westbrook in the loss to Dallas.
Dave McMenamin contributed to the report.