The Los Angeles Lakers announced that they would not be playing against the Philadelphia 76ers because of a sore left knee.
James has a six-day rest after the Lakers next game is on Sunday at New Orleans.
James has missed 19 games this season, continuing a string of bad health since he joined the Lakers. He missed 27 games in his first season with the franchise. James missed only four games in the calendar year, and the Lakers went on to win the title.
James is currently leading the league in scoring with a 30.0 points per game average after his 38 point triple-double against his former team.
After the game in Cleveland, James said he is having the time of his life, despite the Lakers struggles all season long, and insisted he still has something left to play for.
I will play with a lot of passion, a lot of energy, give my teammates what they deserve, and hopefully I can stay injury-free for the rest of the season. We leave everything on the floor so you can control what you want. Just my thoughts.
The Lakers are ninth in the Western Conference with 10 games left.