Supreme Court hopeful Judge Ketanji Brown Jackson is set to start her confirmation hearings on Monday in her bid to become the first black woman to serve on the high court.
Jackson will give an opening statement after the Senate Judiciary Committee gives a speech.
Jackson will not be questioned by lawmakers until Tuesday.
She is expected to field a lot of questions from Republicans about her judicial record and philosophy. Some GOP senators have criticized Jackson's stances on issues such as court packing and the criminal sentencing of defendants convicted of child-pornography charges.
On Friday, the Supreme Court disclosed that its longest serving justice, Clarence Thomas, had been hospitalized with an illness.
Jackson would be the new Justice if confirmed. Replacing one liberal justice with another would maintain the court's 6-3 conservative majority.
Jackson was nominated to the Supreme Court by the president.
Jackson has been on the D.C. Circuit appeals court since last year. She was confirmed by the Senate with the support of every Democrat and three Republicans.
Jackson will need at least 50 votes in the Senate to join the Supreme Court. The vice president holds a tie-breaking vote for her fellow Democrats and the two independents who vote with them.
No Democrats have said they will vote against Jackson.
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CNBC's Jacob Pramuk contributed to the report.