After a number of injuries and illnesses emerged over the weekend, it is possible that Tyrick Mitchell will be called up to the England senior squad for the first time.
The rest of the England coaching staff will meet on Monday to assess those who might withdraw and to decide which players will be added to the squad.
He has a major problem in defence, with only one fit full-back remaining, and he hasn't played since the end of February, after recovering from injury and a bout of Covid.
Trent Alexander-Arnold is out for a few weeks with a hamstring strain, and Thomas Tuchel has made it clear that he wants Reece James to stay with the Blues to recover from injury, rather than join up for two friendly internationals at Wembley.
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Ben Chilwell and Kieran Trippier are both out with long-term injuries and will not be able to play in left back for the foreseeable future.
Mitchell is in a strong position for his first call up despite not having played in any of England's junior teams.
The England boss has noticed the 22-year-old Palace player who has played 33 matches this season.
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He was very close to a call-up, and I think he has been very good with his defense.
He is one that we could have changes over the weekend.
There are four right-backs in the U21 squad.
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Tino Livramento, Tariq Lamptey, Ben Johnson, and Djed Spence could all make the step up to the senior team.
Jordan Pickford is still recovering from illness and is out for a few weeks with a muscle strain, but he did play in the loss to Palace yesterday.
England's players have an extra day off as they head into their first international training camp of 2022, with the squad due to report at St George's Park on Tuesday.
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The other attacking players in the squad are slightly ahead of him at the moment.
Many will be surprised by the omission of the Manchester United winger.
The 21-year-old was left out of the previous camp in November after just four starts in the league, but he has been back to his best under the interim boss.
Lothar Matthaus, an ex-Germany international, told Sky Sports News that he made a mistake when he left the club.
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Jordan Pickford, Nick Pope, and Aaron Ramsdale are the goalkeepers.
Goalkeepers: Trent Alexander-Arnold, John Stones, Ben White and Harry Maguire.
Quarterbacks: Jude Bellingham, Jordan Henderson, Mason Mount, and James Ward-Prowse.
The forwards are Tammy Abraham, Phil Foden, Jack Grealish, Harry Kane, Emile Smith Rowe.
They are friends.
Saturday, March 26: Switzerland
The Nations League.
June 8: Germany, June 11: Italy, June 14: Hungary, September 23: Germany.
The World Cup starts in November.