There is a mystery about how the disease may cause brain fog in some people. In the first two years of the Pandemic, roughly 81 million Americans contracted COVID-19. Many are grappling with long-term symptoms that affect the brain and other body systems. Get market news that is relevant to you. You can subscribe for free. It affects millions of people and leads to them not being able to work the way they used to, or to lose time from work. There is an urgent need to research the disorders and develop therapies, according to a January Science perspective. Koralnik says that it is the third most frequent neurological condition in the U.S. Researchers are trying to find out if the virus is damaging the brain, if it is breaching the protective blood-brain barrier, and if the effect is permanent. Most of the accumulated data is based on adults, so there is less known about how the virus affects the brains of older teens or children. The blood-brain barrier can prevent many germs from reaching the brain, but it can also allow certain pathogens to get in. Recent studies suggest that the ability to directly cross that barrier is possible. The brain can inflame the brain-barrier cells and that this inflammation can be transmitted into the brain from the cells near the brain. Koralnik's team published a study this week that showed that the brain's supportive glial cells are activated and that there is inflammation. Some studies link brain damage to the virus, but not all of them. A study of 785 people aged 51 to 81 published this week in Nature shows that after a year or two after being exposed to COVID, some people show as much as a decade of normal aging. The co-author of the paper says that people with mild cases showed cognitive decline and brain damage. If you compare the number of gray matter lost in a given brain region by participants with and without the Pandemic, you will see that non-infecting participants will have lost less gray matter over the three-year period. The data available for the study doesn't allow us to indicate a specific mechanism for the effects observed; these can be because the virus invades the brain, or because of the inflammation it causes. The long-term implications are unknown as the brain has a remarkable ability to recover from certain damage. There is concern that it could cause early Alzheimer's or Parkinson's diseases. A study out this week looked at 1,438 COVID survivors and 438 uninfected people from Wuhan, China, all 60 or older, for more than a year. The risk of dementia was found to be much higher in those who had experienced severe COVID. Mild symptoms appear to increase the risk. There is still a lot of unknown, according to Winkler. If the changes are reversed, if they affect younger individuals the same as older ones, and if changes in the brain are related to brain fog, what the best therapeutic options will be. Go deeper. The story was originally published on March 10. Do you like this article? You can get more from Axios for free. The leader of Hong Kong warned that the outbreak of coronaviruses has yet to reach its peak as China instituted new restrictions that included urging the public not to leave Beijing. There were five new cases of the H1N1 in Beijing and part of the Yosemite housing complex was locked down. Daylight saving time may cause you to be sleepy, clumsy and distracted. You can speak in 43 languages with this invention. The US has more self-storage facilities than McDonald's, Wendy's, Burger Kings, Starbucks and Walmarts combined. It matters because we're overstuffed. All that stuff brings a lot of stress. Stay on top of the economic and market trends. 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The sub-variant is more transmissible than Omicron according to Professor Adrian Esterman. The best Amazon Canada deals this weekend include headphones, air fryers, and everything in between. There are 30 hilarious photos of things that happen only in China. The first part of Battle of the Brains Season 19 Episode 20. It does not fit! The series is for children of all ages. If you have a question, send it to curiouskidsus@theconversation.com. Evie H., age 9, Seattle, Washington asked why different countries have different electric outlet plugs. What is that outlet? It has holes in it. A. How long should the symptoms last? After recovering from the virus, some people experience side effects that are confusing and alarming. The editor in chief of the Harvard Health Letter says how long these illnesses last remains to be determined.How it works