There is a short research brief. The sperm of older rats is different from that of younger rats in ways that may affect embryo development, according to recently published research. Instructions that determine which genes will be turned on or off in offspring can be found in sperm. Epigenetic information is what these directions are known for. The activity of many genes in sperm was affected by the age of the rats we studied. We found that age affects two epigenetic mechanisms, one of which is the altering of DNA to block specific genes. People are having their first child later in developed countries. Over the past three decades, the number of men between the ages of 35 and 44 who are fathering children has increased. Children conceived by older fathers have a higher risk of health problems. There are many different forms of cancer, as well as other disorders such as attention deficit/hyperactivity disorder. The quality of information transferred by sperm decreases with age. We don't know if these changes occur through an accumulation of genes or something else. Epigenetic changes are thought to be a culprit. We collected sperm from old rats in our experiments. The ages are between 20 to 25 and 40 to 45. The sperm of older rats had different epigenetic profiles than younger rats, and we analyzed it using methods based on DNA sequencing. In older rats, 5,319 DNA sites had different levels of methylation. 5% of all rat genes may be affected by the number of sites we found. Older rat sperm had different concentrations of smallRNAs, which can interfere with the expression of genes. 3.6% of the smallRNAs we identified were different in older rats. Changes in smallRNA can affect multiple genes. The genes that were affected by these epigenetic mechanisms were identified using a computer program. The brain and other organs are regulated by most of the genes we identified. The study only analyzed sperm, not offspring. Knowing which genes are likely to be turned off allows us to predict what will happen in the development of rat pups. If the same mechanism exists in humans, it may be possible for children conceived by older fathers to have a higher risk of certain health conditions. Similar age related changes occur in human sperm. The study of human sperm is still in its infancy. Epigenetic information is flexible and can be altered by many lifestyle and environmental factors. We hope our research will help to develop future therapies that can address the health of children before they are conceived. You can get insight in your inbox each day. You can get it from The Conversation's email newsletter. The Conversation is a news site dedicated to sharing ideas from academic experts. It was written by Alexander Suvorov. Read more.The Conversation
The big idea
Why it matters
How we do our work
What still isn’t known
Alexander Suvorov is funded by the US National Science Foundation and the Russian Science Foundation.
Donald Trump spoke at a rally. The first impeachment focused on withholding military aid.
Donald Trump told rallygoers in South Carolina to "lay down their lives" to defend the US against Critical Race Theory.
Few know that Amazon has millions of Prime subscribers.
The US lost 1.3 million acres of farmland in the year 2021, according to the latest report from the USDA. The total land in farms decreased from 2020 to 2021. An average loss of 1.9 million acres per year has been recorded since the beginning of the year. One of the main causes of the Shrinking is the conversion of agricultural land into new developments.
Nature is both beautiful and terrifying, as shown by the sharks. They are the only animal that has earned an entire week of television devoted to them and they are also the stars of the most famous and successful franchise of creature features ever made. The Great White shark is a model for what it means to be a pure predator. A couple thousand pounds of pure muscle and teeth. There is nothing bigger than the oceans when it comes to terrifying animals.
Raleigh News and ObserverThe poor in America have always been demonized, but don't they deserve to be able to shop in a nice store, clothe and feed their families?
Thanks to people using their video cameras more in intense situations, there is a new sheriff named Karen.
There were 1,807 new local COVID-19 cases in China on Sunday, the highest daily figure in two years and more than triple the previous day. China has a lower case count than many other countries, but the growing number could complicate Beijing's ambition to suppress the spread of disease. The surge prompted health authorities to allow the public to buy rapid self-test kits for the first time to help detect infections quickly.
The judge writes that if the teen is guilty, he deserves more severe punishment than the court can impose.
Paris Jackson has been taking over the world, between beautiful performances in Paris to now, showing her silly and sexy side in a nude, candid shot. On March 7, Jackson posted a series of photos to her social media accounts. She tagged it instead of posting a caption.
Ad•PlayJunkieA hydra can live until the end of time if undisturbed. There are many animals that have long life spans.
After a court filing by Alec Baldwin, the armorer on the set ofRust spoke out. Jasmine Viel reports.
On Tuesday, we told you about a new initiative called Project HEAL, which is dedicated to addressing the various challenges of today's marginalized youth and at-risk communities. The news may seem like a good thing, but some people aren't happy with Scott's latest move.
In its cold open, SNL once again zeroed in on the war in Ukraine, with a sketch that featured President Joe Biden and White House press secretary Jen Psaki consulting with TikTok stars on how to respond to the growing threat. James Austin Johnson was back in the Oval Office.
Ad•YourDIYThe experts can't explain the strange things discovered on Mars.
Those without a bachelor's degree earn $24,900 less each year than those with a degree.
Country singer Drake White says on the PEOPLE Every Day that it is so life-giving to be out here, after doctors said he wouldn't walk again.
Has President Biden lost a liberal comedian?
This is what it was like to be a warrior.
IndyStar | The Indianapolis StarThe first ant in Indiana to have a sting is the Asian needle ant.
The bill would make it a crime to end ectopic pregnancies. The bill would ban out of state care.
The film is now available for streaming.
Ad•Amazon.com
Russia has responded to sanctions by banning the export of Russian-made cars, but a Russian-made car is just a drunk bear on roller skates.
ProFootball Talk on NBC SportsTom Brady attended the Manchester United match against Spurs on Saturday. That headline could be just another piece of a puzzle that eventually leads to a much more significant headline. The family that owns the Buccaneers own Manchester United.
Baseball players were divided when it came time to vote on the deal. The team player representatives voted 26-4 in favor of the deal, leaving the overall ballot at 26-12 for the vote.
All Rights Reserved © 2024
