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This article is about Nature. 71k accesses. 8071 is a Altmetric. There are metrics. We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply. There is strong evidence for brain-related abnormality. It's not known if the impact of the disease can be detected in milder cases or if it can reveal mechanisms that contribute to brain pathology. We studied brain changes in 785 UK Biobank participants who were imaged twice, and found that many of them had positive tests for the disease between their first and second scans. Pre-existing risk factors are less likely to be misinterpreted as disease effects if the data is available. There were significant longitudinal effects when comparing the two groups, including greater reduction in grey matter thickness and tissue-contrast in the orbitofrontal cortex and parahippocampal gyrus. Between the two timepoints, the participants with the infections showed larger cognitive decline. The effects were still seen after the 15 cases who had been hospitalized were excluded. The results of brain scans may be indicative of the spread of the disease via olfactory pathways, or of the loss of sensory input due to anosmia. The effects of this impact are still being investigated, whether they can be partially reversed or if they will persist in the long term. Supplementary Discussion and additional references are included in the file, as well as Supplementary Longitudinal Plots, Supplementary Baseline Plots, Supplementary Analyses and additional references. There is a full list of IDPs used in the hypothesis-driven and exploratory approaches. There is a full list of IDPs used in the hypothesis-driven and exploratory approaches. There is a full list of IDPs used in the hypothesis-driven and exploratory approaches. The full list of non-IDPs is used for the cross-sectional, baseline comparison between the two groups. There is a full list of IDPs used in the hypothesis-driven and exploratory approaches. You agree to abide by the Community Guidelines when you submit a comment. If you find something that does not comply with our guidelines, please flag it as inappropriate.
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