Rose has an ankle problem and it continues to bother him.
The team announced Friday that Rose will have a procedure on his ankle and that a timetable for his return has not yet been determined.
The Knicks signed the NBA's Most Valuable Player to a three-year, $43 million contract last summer.
It was a well-deserved deal for Rose, who was traded from the Detroit Pistons to New York to begin his second stint in blue and orange.
He helped guide the Knicks to a 17-6 finish, which catapulted New York to the Eastern Conference's 4 seed and the team's first playoff appearance in eight years.
In 35 games for New York last year, Rose averaged 14.9 points and 4.2 assists, but he was the only consistent and productive offensive threat.
He averaged 19.4 points for the Knicks as they fell to the Atlanta Hawks in the first round.
The Knicks' offense has taken a massive tumble as the team struggles near the bottom of the Eastern Conference. They are ranked 25th in offensive rating and 27th in points per game.
The team could use Rose back as soon as possible because he fills a vital role on the bench.
He has been unable to take the court multiple times because of his ankle problem.
He was out for three games in November because of ankle pain.
The team said that Rose had a sore right ankle and left the game.
He missed the next two games against Boston and Detroit. The Hospital for Special Surgery in New York is where Rose had successful surgery on his ankle. He would be reexamined in eight weeks.
The Knicks have a 25-34 record. They trail the Hawks by three games for the final spot in the play-in tournament.