| Venue: Twickenham Stadium Date: Saturday, 26 February Kick-off: 16:45 GMT |
| Coverage: Listen to match commentary on BBC Radio 5 Live, BBC Radio Wales and BBC Radio Cymru; text commentary and highlights on BBC Sport website and app. |
Centre Joe Marchant has been left out of England's 25-man squad to face Wales at Twickenham on Saturday.
Tuilagi and Lawes are both expected to make their Championship debut after recovering from concussion.
Joe Launchbury was released back to the English club.
Eddie Jones will make his starting XV on Thursday.
Sam Simmonds has recovered from a hip problem to be included in the 25 and will compete with Alex Dombrandt for a start at number 8.
Jack Nowell was declared fit after recovering from a concussion.
England started their campaign with a loss to Scotland at Murrayfield before beating Italy 33-0 in Rome.
The attack coach says they must win to keep their hopes of winning the Six Nations alive.
It is a big game and we are treating it like a quarter-finals.
It is knockout stages for us. Wales will make it difficult for us.
We have to go into this with a mentality of going after Wales.
If we don't get the result on Saturday, we're out.
The forwards are Chessum, George, Itoje, Isiekwe, Lawes, Marler, Rodd, and Stuart. Backs: Tuilagi, Ford, Ford, Nowell, Randall, Randall, Smith, Steward, and B Youngs.
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