Sequencing puts carnivore chromosomes in context

The studies tend to focus on the sequence of the genes. A new study by researchers at the University of California, Davis shows how the three-dimensional scaffolding of chromosomes is related across several species of animals. The work published in the week of February 21 shows the power of large collections of genomes.

The researchers used a technique called Hi-C to identify the three-dimensional shape of the conformation. They were clouded leopard, leopard, tiger, tiger, puma, dingo, African wild dog and red fox. The data came from the Earth BioGenome Project.

There are two parts to the human body, the nucleus and the cells, which are called chromosomes. The structure of the chromosomes is organized into loops, associated domains, compartments, and territories.

The structure of the chromosomes was served.

The Hi-C analysis looked at the chromosomes. The genes are shown in three-dimensional space in the cell nucleus. Being close can affect how genes are turned on or off.

Despite 50 million years of evolution, the 3D chromatin structures were highly conserved for genes that are orthologous, or related by descent. This shows that the genes are coding.

The approach of comparing three-dimensional structures in chromosomes could make it easier to identify related genes across groups of animals and plants.

The goal of the Earth BioGenome Project is to provide a complete DNA sequence catalog of all 1.8 million named species of plants, animals and fungi. The goal of the project is to create a reference genome that is error-free and will allow the study of how genes have contributed to the evolution and survival of these species.

More information: Conservation of chromatin conformation in carnivores, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2120555119. Journal information: Proceedings of the National Academy of Sciences Citation: Sequencing puts carnivore chromosomes in context (2022, February 21) retrieved 21 February 2022 from https://phys.org/news/2022-02-sequencing-carnivore-chromosomes-context.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.