The British Medical Association said that ending all Covid restrictions is premature and not based on current evidence.
The legal requirement to self-isolate in England will be lifted a month earlier than planned, with a formal announcement expected on Monday, according to Boris Johnson.
The prime minister wants to claim victory for weathering the Omicron wave and for being able to regulate daily life.
Dr Chaand Nagpaul, chair of the BMA council, said the decision was not based on current evidence and was premature.
One in 20 people in England were thought to have been exposed to the disease last week, according to the latest Office for National Statistics survey.