Fat Cells in Our Skin Could Be Key to Fighting Acne, Scientists Discover

The cells in our skin could be involved in the cause of the skin problems. Recent experiments on human and mouse skin have shown that the fat-produced fibroblasts regulate the appearance of the skin.

Fibroblasts are the most common type of cell in our bodies and are critical to wound healing. Their role in the problem has been overlooked.

A group of skin fibroblasts can be triggered by the Cutibacterium acnes bacterium, which is responsible for causing inflammation in the skin.

The fibroblasts appear to be stimulated to turn into fat cells when confronted with this infection. This process also causes the release of a peptide with antimicrobial properties.

Richard Gallo from the University of California San Diego says that the findings may change the way we treat the skin condition.

Previously, it was thought that hair follicles were the most important for the development of the skin condition. In this study, we looked at the cells outside of the hair follicle and found they had a major effect on controllingbacteria and the development ofAcne.

There are still some gaps in our understanding that scientists continue to chase, but over the years, research has unearthed a slew of factors and underlying mechanisms that can lead to it.

Research has focused on the hair follicle and its oil glands, which help to clear away dead skin cells and dirt. The inflammation that can be caused by the release of toxins and other local effects can be caused by the proliferation of certain types ofbacteria within the follicle.

retinoids are useful for the treatment of severeAcne, as they can help to reduce inflammation They could also help in another way.

retinoids can enhance the expression of cathelicidin among some skin fibroblasts, while also reducing the growth of morebacteria due to the presence of newly spawned fat cells.

The authors write that the influence of fibroblasts on the development of the skin appears to reflect a balance between the host and the microbe.

Cells stimulated by C. acnes express cathelicidin, which has activity against C.

It is a double-edge sword, but if we can figure out how to dull one side of the immune attack, it could help treat acne more directly.

retinoid treatments can cause fetal abnormality if a patient becomes pregnant, so they are only used in severe cases. If researchers can figure out what causes the fibroblast to make cathelicidin, we might be able to give it a boost with less side effects.

It was interesting to find that cathelicidin was so high in expression in the tissue.

Knowing this will be helpful in developing a more targeted therapy to treat the problem.

Science Translational Medicine published the study.