Lymphatic System: Facts, Functions & Diseases

The lymphatic system is a network of tissues and organs that help rid the body of toxins. The journal Lymphatic Research Biology states that the primary function of the lymphatic system is to transport lymph, a fluid containing white blood cells, throughout the body.

The veins and capillaries of the circulatory system are similar to the lymphatic vessels. The vessels are connected to a body of water. The immune system is made up of the tonsils, adenoids, and spleen.

Description of the lymphatic system

The human body has hundreds of cells. According to the American Cancer Society, they can be found deep inside the body, or under the arm or groin. The head and knee area are where the lysies are located.

The largest organ in the body is the spleen, which is located on the left side of the body.

White blood cells called lymphocytes, which act as defenders against invaders, can be created by the spleen and the lysy as a result of potentially dangerousbacteria, viruses, or other microorganisms in the blood. The immune system can kill foreign organisms and stop them from spreading. Humans can live without a spleen, even if they have lost it to disease or injury.

The chest is where the thymus is located, according to the manual. This small organ stores immature white blood cells and prepares them to become active T cells, which help destroy infections or tumors.

There are tonsils in the pharynx. They are the first line of defense for the immune system. Although tonsillectomies are less common today than they were in the 1950s, they are still one of the most common operations performed.

According to the National Lymphadema Network, the word lymph comes from the Latin word lympha, which means connected to water.

The body&s cells are left after it has delivered its vitals and removed debris. Most of the fluid returns to the circulation through small blood vessels called venules. According to the National Cancer Institute, the remainder becomes sputum.

Lymph flows upward toward the neck, unlike blood which flows throughout the body in a continuous loop. According to the National Cancer Institute, the fluid re-enters the circulatory system when the Lymphatic vessels connect to two subclavian veins.

Diseases and disorders

Immunology is used to treat diseases and disorders of the lymphatic system. Various medical professionals get involved in the treatment of diseases of the lymphatic system. Manual drainage of the lymphatic system is a specialty of lymphedema therapists.

Dr. James Hamrick, chief of medical oncology and hematology at Kaiser Permanente, said that the most common diseases of the lymphatic system are enlargement of the lymph nodes, swelling due to lymph node obstruction, and cancer involving the lymphatic system.

Infections can cause swelling in the lymph fluid when there are more white blood cells than usual. The swollen nodes can be felt in the neck, undergarment and groin.

Infections, inflammation, or cancer are the most common causes of Lymphadenopathy. The area of the infection may cause the enlargement of the lymph nodes. In some areas of the body, the enlarged lysies can be felt, while others can be seen on a computed tomographic (CT) or magnetic resonance (magnetic resonance) image.

When a person's immune system is active, it can lead to enlargement of the lysies. This can happen in the disease.

There is a disease: lymphoma.

This refers to cancer in the body. It happens when the lymphocytes grow uncontrollably. There are different types of lymphoma, according to the director of research at the Willamette Valley Cancer Institute.

The first branch point is the difference between the two diseases. The American Cancer Society says that non-Hodgkin lymphoma is the most common cancer in the US. Around 80,000 people in the US will be diagnosed with the NFL in 2022.

An illustration of lymphoma cells

A 3D illustration of lymphoma cancer cells.  (Image credit: Getty Images)

Follar is the most common type of NHL, accounting for 30% of all cases, followed by diffuse large B-cell lymphoma, which makes up 40% to 50% of NHL cases, and Burkitt's lymphoma, which makes up 5% of NHL cases.

Though there can be a significant range within an individual category, the clinical approach to each category is unique and the expectations of patient outcome varies by category.

When a person has had surgery and/or radiation to remove a cancer, the lymphatic flow back to the heart can result in swelling or lymphedema. Women who have had surgery to remove a breast cancer are more likely to experience this. The removal of the breast cancer's cells involves removing them from the armpit.

The risk of chronic swelling and pain due to lymphedema in the arm is higher for people who have more lymph nodes removed.

There is research done on why people might get lymphoma. VU University Medical Center in Amsterdam researched a Dutch pathology registry. The risk of developing anaplastic large cell lymphoma in the breast is 1 in 35,000 at 50, 1 in 12,000 at 70, and 1 in 7,000 at 75 according to the research. The study was published in a journal.

Castleman disease is a disease.

According to the Castleman Disease Cooperative Network, this disease refers to a group of inflammatory disorders that can cause multiple-organ damage. It is a type of cancer that is similar to a lymphoma and is often treated with chemotherapy. It can be either one or multiple.

Lymphangiomatosis is a disease.

According to the Lymphangiomatosis and Gorham's Disease Alliance, this disease involves multiple cysts. It is thought to be the result of a genetic change.

Lymphatic filariasis is a disease.

According to the Centers for Disease Control and Prevention, this is a neglected tropical disease that is caused by a thread-like worm. There are many cases of filariasis caused by the Wuchereria bancrofti. Millions of these worms can enter a person's bloodstream through mosquito bites, and then travel to a lymph node where they will grow and reproduce. The majority of cases of filariasis show no outward signs of the disease, according to the WHO. It can cause skin and tissue problems called elephantiasis. People living in tropical or sub-tropical areas are at the greatest risk for getting the disease. According to the CDC's FAQ page on Lymphatic filariasis, short-term tourists have a low risk.

There are tonsilloliths.

There are tonsil stones that can happen to the lymphatic system. White blood cells attack the debris and leave behind a hard biofilm that breathes oxygen. They are not smooth like regular stones and look like they have crevices wherebacteria can accumulate. Sometimes tonsil stones need to be manually removed.

A tonsil stone inside a mouth

A tonsil stone begin as soft clumps of trapped bacteria, food and white blood cells and then calcify into hardened stones.  (Image credit: Getty Images)

Diagnosis and treatment

When the lymphatic system is enlarged, diseases are usually diagnosed. This may be discovered when the lymph nodes become enlarged enough to be felt, or if they are seen on an x-ray.

The majority of enlarged lymph nodes are not dangerous because they are the body's way of fighting off an infectious disease. If the lymph nodes become larger and persist longer than the infection, they are more worrisome. There is no specific size cutoff, but typically the larger the nodes, the more worrisome they are and should be examined by a doctor.

Swelling of the arm or groin, weight loss, and night sweats are some of the symptoms of a lymphatic disorder.

The location of the abnormal lymph nodes and other things that are going on with the patient are what determines the diagnosis of lymphadenopathy. If the patient has a known infection, the lysing can be followed to await resolution of the problem. If the nodes are growing quickly and there is no obvious explanation, then a biopsy is usually needed to look for a cancer or an infection. If the nodes can be felt, then this can be done at the bedside with a needle.

The needle might need to be placed in the deeper part of the body, such as the abdomen or the pelvis, according to Hamrick. Sometimes a surgeon is needed in the operating room to do the biopsy. He said that this is where the most tissue can be obtained to make a diagnosis.

There are different treatment options for different types of leukemia. Treatments can include traditional chemotherapy, immunotherapy, and even radiation.

Treatment of diseases in the lymphatic system depends on the underlying cause. While the immune system does its job, infections are treated with antibiotics and supportive care. Physical therapy and compression can be used to treat lymphedema. The treatment of cancer in the lymphatic system is a combination of therapies.

There have been a lot of new treatment options in the last few years. Ibrutinib, idelalisib, nutobiuzumab, lenalidomide have been approved in various indications and it is likely that we will see more in the future.

Additional resources

You can find more information about lymphoma at the charity Lymphoma Out Loud. Immune: A Journey into the Mysterious System That Keeps You Alive is a book for a deeper dive into the immune system.

Bibliography

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  • Antonino Carbone et al, "Follicular lymphoma," Nature Reviews Disease Primers, Volume 5, December 2019, https://doi.org/10.1038/s41572-019-0132-x
  • Naritee Sukswai et al, "Diffuse large B-cell lymphoma variants: an update," Pathology, Volume 52, January 2020, https://doi.org/10.1016/j.pathol.2019.08.013 
  • Guillermo Oliver et al, "The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease," Cell, Volume 182, July 2020, https://doi.org/10.1016/j.cell.2020.06.039