George Ford's last England appearance was in a 32-18 loss to Ireland.
The fly-half was called up to the England's Six Nations squad, giving him the chance to revive his international career.
Since the defeat by Ireland last March, the fly-half has not played for England.
Eddie Jones has turned to Ford to replace Owen Farrell.
May withdrew due to a knee injury.
The favourite to captain England in Farrell's absence is unavailable to train this week as he is undergoing head injury return to play protocols.
Injury cover for Lawes has been provided by the addition of Nick Isiekwe.
'On-form' Simmonds deserves a spot in England.
Ford was overlooked for the autumn Tests despite his outstanding club form.
Farrell is still in the England squad despite his injury.
Farrell will miss at least the first part of the Championship after sustaining an ankle injury in club training. The 30-year-old is going to see a specialist this week.
Farrell missed the last two months because of an ankle problem, not the one he picked up against Australia.
Jones had planned to put Smith and Farrell together in the England centre, but now he will have to look at other options.
The Calcutta Cup match between England and Scotland will be played at Murrayfield on 5 February.
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