Luminescent sensors developed for highly-sensitive detection of semicarbazide and heparin

There is a fig. There is a schematic diagram of upconversion luminescent nanoprobe. Credit: ZHU Jiawen.

A research team led by Prof. Jiang Changlong from the Hefei Institute of Physical Science (HFIPS) of the Chinese Academy of Sciences has developed two nanoparticles that can detect semicarbazide and heparin.

The researchers use the lanthanide-doped up optical materials to convert low-energy near-IR photons into high-energy short-wave visible photons.

There is a widespread food contaminant that can cause cancer and nerve damage. Due to the lack of optical response of traditional methods, it is difficult to construct an efficient and sensitive optical detection method.

The sensor had high sensitivity and a visual response to semicarbazide, which was found in the range of 0–16 M.

Difficulty in coagulation can be caused by the drug heparin, which can easily lead to high concentration.

The heparin sensor is a novel solution to the problems of autofluorescence and photobleaching. It has a detection limit of 0.1 nM in the colorimetric mode and a detection limit of 0.3 nM in the fluorescence mode.

There is a fig. There is a schematic diagram of upconversion luminescent probe. Credit: ZHU Jiawen.

The accuracy of the sensor is improved by relying on long-wavelength excitation to eliminate autofluorescence, and by expanding the clinical detection of heparin and related medical safety applications.

The research student said that the sensors are good for food safety and human health monitoring.

More information is available in the paper by Jiawei Zhu et al. The book is titled "Anal Chem."

A dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin is being developed. The article is titled "SNP.2021.130378".

Analytical chemistry journal information.

There were glowing sensors developed for highly-sensitive detection of semicarbazide and heparin.

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