The FA Cup third-round clash with Swindon Town will be missed by Guardiola after he tested positive for COVID-19.
The game is scheduled to go ahead on Friday with Rodolfo Borrell in charge.
The City statement said thatPep will miss the FA Cup game against Swindon Town after testing positive for carbon dioxide.
Manchester City is struggling with an outbreak of COVID-19.
The City manager and assistant Juanma Lillo had positive tests on Tuesday. Both are isolated, along with a number of other positive cases within the City first team bubble.
There are 21 people who are isolating for COVID related reasons. Seven first team players are part of the backroom staff.
Rodolfo Borrell will be the assistant coach for the trip.
The plan is to mix available first-team players with the academy to make sure they can field a team at Swindon.
Pep has the virus but he doesn't have a lot of symptoms," he said. Thanks to the technology, we are always in touch via the phone.
It has been one of the easiest lineups we have to make. We will play with the ones we have. We don't have much more.
We can fill the team at the moment. I don't know what will happen in the next few days. We will play with what we have, some first-team players and some players from our second team.
