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Nuclear pore complexes act as passageways for the transport of molecule into and out of the nucleus. Nuclear transport is a target for possible therapies because it is linked to many diseases such as viral infections, cancers and certain neurodegenerative diseases.
Researchers from the Boston University School of Medicine have created a model of the yeast's core scaffold using rapid plunge freezing and cryo-EM to show how the scaffold is connected.
Christopher W. Akey, the author of the research, said that the research provides new insights on multiple levels into the functions of the transport machine.
This model will give researchers a better understanding of how mega-channels assemble and how they can adapt to changes in transport. The ability of this assembly to use interchangeable parts to modify its architecture on the nuclear side is reflected in the fact that we have observed multiple types of NPC in the same cell for the first time. The functions of these machines may be tailored for different environments at the center of the nucleus.
The researchers believe that these findings will set the table for studies of how viruses may alter the cell's biology to cause disease.
The journal Cell has these findings online.
Michael P. Rout has a paper on the structure and functional adaptation of the yeast nuclear pore complex. There is an article in the Cell.
The journal contains information about the cell.
The model of yeast nuclear pore complex was retrieved fromphys.org on January 3, 2022.
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