Tuchel said that he may have to use players from the U23s and academy for the Carabao Cup clash at Brentford, adding that he is sad that his team are unable to compete at the highest level.
Seven first-team players were ruled out for the Wolves game because of the recent spike in Covid cases.
The other six players are still absent, but one of them, Jorginho, is able to return for Wednesday's quarter-final against Brentford after it was confirmed he had recorded a false positive.
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Wolves vsChelsea highlights.
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There are highlights from Wolves' draw with Chelsea.
With a run of four matches in 12 days and battling to keep pace with Manchester City in the title race, Tuchel says he may have no choice but to call on the club's inexperienced young players at Brentford.
The head coach said that they trained with them. They were made to come for two training sessions.
We brought in the academy to protect our players and we think about playing with them.
Tomorrow we will not take any risks with some of our players and we will focus on the health.
This is against our nature and maybe we have to do it. This is not what sport is about and this is not what we are about.
We are so competitive that the players signed for us. We are fighting for the win.
I don't like judging games because you can't tell. Winning, performing and fighting together are the most important things.
The German says that he had to recall N'Golo Kante and Mateo Kovacic to his squad for the game at Wolves despite the duo having just a few training sessions between them.
Lewis Baker has become the latest player to test positive for Covid, as Tuchel added that both Andreas Christensen and Trevoh Chalobah are doubtful for the game at Brentford.
"What we did with N'Golo Kante, 90 minutes, was close to being irresponsible," said Tuchel. Will he be in the squad? No.
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The match against Wolves was not postponed due to the Covid outbreak.
Would it be possible if it was the last game of the season? Yes, but we can't do it and I won't do it. We will give him time to recover and prepare for the match.
This is not a big problem if you have a team with 13 or 14 players. We are paying for this because from the match we had N'Golo Kante and Mateo Kovacic involved, which was taking a huge risk.
It's impossible to start five matches in two weeks. We can't let players suffer because other players aren't there.
Despite his frustration at the current situation, Tuchel admits he is still looking forward to navigating the busy festive fixture schedule.
This is actually quite exciting for the former Paris Saint-Germain and Borussia Dortmund boss, as he is used to enjoying a winter break at this time of year.
I watched it when I wasn't involved and now I am in the middle of it. It is nothing new to play three matches in a week, but to play three matches in a week without a lot of players is challenging.
We love to be involved in these contests. We find solutions even though we struggle a little. This will be the situation for a long time because it will not stop.
The first-team squad is likely to be supplemented by U23 and academy players.
Despite calling for the game to be postponed because of the number of positive Covid cases in his squad, Tuchel says he is not disappointed.
The clubs in the premier league decided not to delay a full round of games.
The league maintained that the fixtures would continue where safe possible after six of the 10 matches were called off.
Jorginho is struggling with a back issue but could face Brentford after Tuchel said his Covid test was a false positive.
On Sunday, they will play Villa away and then face the Seagulls three days later. The title race could be decided on January 2 when the Blues host the Reds.
Tuchel said he didn't have a solution for the whole league, and that he was disappointed at the decision not to implement a circuit-breaker. I don't know if it would have delayed the problem.
It would have been better for us to have a short break because some clubs suffer a lot. We could have played against another team who was going to suffer in the next moment.
I don't know what's best for everyone because we are not alone in the league. We are disappointed that we don't have the players to fulfill our goals and play at the highest level.
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