After returning a negative test, the Manchester City boss is free to take charge of the team's trip to the north.
The result of a test that he took on his arrival at City's training ground on Friday was not conclusive.
The former Barcelona head coach traveled to Catalonia this week to attend a retirement news conference.
A 10-day isolation period would have ruled him out of the game at St James' Park and the Boxing Day visit ofLeicester City.
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Manchester City's win over Leeds in the premier league is free to watch.
In the week before the game against the Falcons, the Manchester City coach urged his team to maintain their winning ways.
"Everyone is fit, it's just Ferran who is missing," said the coach. "Everyone is ready to play and Joao Cancelo is back after his suspension against Leeds."
It is not easy to get a result in the middle of the season and we will need the whole team to be strong enough to get the points.
It is a very difficult opponent. You know what to expect when you go to a game at Newcastle, people will talk about our place in the table or their place in the table, but you know what to expect.
We know what a good manager Eddie Howe is.
They have had a tough start to the season but they are a good team with good players and a top manager so we will have to work hard for each other to win the game.
The effects of long Covid are discussed by De Bruyne.
Kevin De Bruyne scored twice for Manchester City in their victory over Leeds, but he still feels the effects of Covid-19.
After testing positive for coronaviruses last month, De Bruyne says he is not back to his best.
I'm not good yet. My body is still adapting. He told Belgium's Het Laatste Nieuws on Thursday that he sometimes feels like he has had Covid after a few sprints.
He had a nagging ankle injury last season, but he feels things are picking up now.
"It's getting better," he said. This season is what it is. I can't help it. I got punched in the face and kicked in the ankle. It's not easy with a busy schedule, but I'm okay. I'm doing what I have to do.
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