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The nucleus of a cell is surrounded by two layers of the nuclear envelope, which protects it from outside damage.
The nuclear envelope can sometimes be broken and torn. This can happen when the nucleus is under pressure from the cytoskeleton.
A new study shows how pressure is relieved from the cytoskeleton.
"Uncovering the mechanisms that underpin the repair of damaged tissue is a fundamental question in cell biology and a better understanding of this process has broad implications for human diseases such as cancer, cardiovascular disease, or autoimmunity," says Dr.
The research shows that the ESCRT machinery is responsible for resealing the nuclear envelope.
The paper focuses on a specific part of the ESCRT. It shows that BROX is a key factor in allowing the nuclear envelope to reseal.
BROX is attached to the envelope by the ESCRT machinery. This allows BROX to apply excessive pressure on the nuclear envelope by binding to the LINC complex.
The LINC is being removed from the site. The nuclear envelope can repair itself if the stress is reduced.
The results show that the nucleus is an organelle that can interact with the cellular environment, which supports the idea that the nucleus is not just a protective case for DNA.
The results could have implications for cancer research as a damaged nuclear envelope is associated with cardiovascular diseases. There are BROX genes that have been found in nonmedullary thyroid cancer. Future research can look into whether BROX causes tumors.
Dr. Agromayor said that the work shows the importance of collaborative research. We were fortunate to join forces with the physics department at King's and the laboratory of Sergi Garcia Manyes.
The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair. There is an article in the journal, titled, "Decel.2021.10.022."
The journal contains information about the cell.
The research shows how damaged cell nucleus reseals and repairs itself.
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