One of the fringe players is likely to start.
If he doesn't change his side for the final game of the group stage, he will be in for a rude awakening from his medical team.
The Reds play nine games in December.
Five wins from five has helped the side to top spot in Group B.
"We have to change, we will change," said Klopp.
If I played the same side again, the medical department would destroy me.
Everything you need to know about the club is in one place.
Absent from the squad are Roberto Firmino, James Milner, Harvey Elliott, and Joe Gomez, but they are all back in training and could feature.
Some of the options to be given a start are Ibrahima Konate, Takumi Minamino, Alex Oxlade-Chamberlain and Kostas Tsimikas.
According to Klopp, Divock Origi is likely to start after scoring a late winner at Wolves on Saturday.
It would be his fourth start of the season, two of which have come in the Carabao Cup.
"He'll start," said the German. "Moan is not the right word, but he knocks on my door and we talk from time to time." It's about letting things happen.
Mo, Bobby, and Sadio played behindDiv. If you don't start for us, it doesn't mean you're not world class. Let's keep going, it's a nice story.
He is a positive person. Talented, shoots left and right, quickly, in the air. An interesting package.
That doesn't mean you are a constant starter for the team. Being a regular starter is worse than not being one.
Runners-up spot up for grabs.
Group B has three teams in the running to win the runners-up spot.
Porto is one point ahead of Milan and one point in front of Atletico Madrid. A win for the Portuguese side at home will seal it.
It will be a goal difference between Milan and Atletico as they are both tied on their head-to-head record. The Italians are one goal better off than the Argentines.
Pietro Pellegri picked up a groin problem on Saturday, joining Samu Castillejo, Olivier Giroud and Ante Rebic on the sidelines.
The line is likely to be led by Zlatan Ibrahimovic, who has six goals in 12 matches this season.
The Italian side have been top of Italy's top-flight for a couple of weeks.
Pick your starting line-up. It's up to you, you can either go for the team you want the boss to pick or the one you think he will choose.
