Doctors test players for concussions when they have a suspected head injury.
The saliva test will be used to diagnose concussion.
The league is funding a study to see if saliva can detect concussions.
It is part of an action plan on brain health.
There is a plan to protect football players from the impact of concussions.
The plan said that players will provide baseline samples at three more times after a concussive injury.
A trial was conducted on male rugby union players in February, with the tests performed in a laboratory.
The results were described as "game-changing" and could lead to the use of pitchside saliva tests to diagnose concussion.
Richard Masters, the chief executive of the premier league, said it was important that football came together to work on the issue.
We want to make sure we have the right approach in place to protect the welfare of players, and we need the help of experts.
The Rugby Football Union and the Premiership Rugby will work with the FA to give former football players access to specialist brain health services after retirement.
An updated version of the action plan will be published before the start of next season, with current and former players being consulted on the plan.
Concerns over links between head injuries in football and dementia led to the introduction of concussion substitutes in February.
The family of Sir Bobby Charlton recently revealed that he had been diagnosed with dementia, after he died last year.
In December, former Spurs defender Jan Vertonghen spoke about how he felt after a concussion, and how it affected him.
