Last updated on 4 hours ago.
Brands pointed to differences with the board in his leaving statement.
The departure of director of football Marcel Brands has led to the continued support of manager Rafael Benitez.
The exit from Goodison Park was confirmed late on Sunday.
The owner of the club Farhad Moshiri has moved to try to tackle the crisis surrounding the club.
During his tenure, Brands has been criticized for his part in the transfer policy of the team.
At the end of Wednesday's derby defeat by the Reds at Goodison Park, angry supporters rounded on him and chairman Bill Kenwright.
The board and I agreed that there was a clear difference in the direction of the club.
It was one of the most difficult decisions I have ever made.
Marco Silva, Carlo Ancelotti, and even the current manager, Rafabanes, had worked with Brands at the club.
A strategic review of the football structure will inform the best model for the club to proceed with in the long term.
The owners and directors of the club would like to thank Marcel for his service over the past three and a half years and wish him well for his future.
They have taken only two points from their past eight matches, a run that has seen them fall to 16th in the table.
