Young Boys defeated Manchester United in their first meeting.
There are restrictions on the number of players that can be used in the Manchester United's match against Young Boys.
Anyone entering Switzerland from the UK has to stay away from the country for 10 days because of the new Omicron variant.
The Young Boys party is under scrutiny by Uefa.
If that is the case, a neutral venue should be found, though the game could be moved to a different date.
Young Boys could still get a place in the Europa League if they repeat their victory over the Premier League side in September.
It would cost United millions of pounds if the game was moved.
A surge in cases of coronaviruses across Europe has led to the re-instatement of restrictions in Switzerland.
West ham's game against Rapid Vienna in Austria last week was played behind closed doors as part of a new national lock down, while all matches in the Netherlands are being played without fans after a partial lock down was introduced earlier in the year.
