After falling behind to VfL Wolfsburg in the first half, Erling Haaland came back to score a second-half volley to give the visitors a win.
After coming on as a second-half substitute, the Norwegian scored in the 81st minute, his first goal since October.
With their sixth win in the last seven league matches, the team that crashed out of the European competition on Wednesday moved up to 30 points, two ahead of second-place Bayern Munich.
Next weekend, the top two teams face each other.
A lot has happened in the last few days. The result stands above everything else, because we played a good game.
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Haaland was a second-half substitute.
We are very happy. We have a good week to prepare for the game and we will go into it with a lot of confidence.
The Wolves took a 2-0 lead in the second minute when Wout Weghorst headed in from a textbook break.
Emre Can scored from the penalty spot in the 35th minute after Marco Reus was brought down by Maxence Lacroix.
Donyell Malen scored from a Reus pass for the third game in a row.
Haaland made a second-half substitute appearance and looked as sharp as ever before the big game against the Bavarians.
He scored his 10th league goal in seven appearances in eight minutes and became the youngest ever player to reach 50 goals in the league.
Lille had a late penalty against them.
Lille remained in the bottom half of the table when they were held to a draw by 10-man Nantes on Saturday.
Lille was stuck in 12th place with 18 points from 15 matches, one point behind their visitors who remained in 11th.
Jonathan David's 80th-minute penalty was saved by Lafont after he had been sent off for tugging on Mehmet Celik's shirt.
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The Canadian international's effort was unconvincing and he was able to make a stop.
Burak Yilmaz scored the first goal of the game for Lille, who are top of their group with one game to play.
The ninth-minute goal was set up by Jonathan Bamba and suggested that Lille could break their poor form.
They failed to hold on to their lead for the sixth time this season, as they were forced to give up their lead in the 24th minute.
The defensive attention of both Jose Fonte and Tiago Djalo was not enough to stop the ball from going inside the post.
The effort of a former Manchester United player was cannoned back off the upright.
Lille missed out on a chance to take all three points when Pedro Chirivella missed a good chance with 30 minutes left.
On Sunday, leaders Paris St Germain visit Saint Etienne and Rennes go to Lorient, while second- and third-place Nice and Metz are both at home.
