Schedule guide, picks, fantasy football tips, odds, injuries and more


Rex is concerned about the Bills.

Rex Ryan explains what is going wrong for the Bills as they fall to second place in the East. 1:07

6:30 AM

We have everything you need to know about the Week 12 NFL schedule for the 2021. The biggest keys to every game are brought to us by our reporters, as well as bold predictions for each game and final score picks.

The Football Power Index (FPI) goes inside the numbers with a game projection and a big stat to know, as well as providing a betting tip for each contest. Kyle Soppe gives out helpful fantasy football insight. Everything you need to know is here in one place to help you get ready for the game.

The full Thanksgiving Day slate includes an offensive battle between the Raiders and Cowboys and an NFC North game between the Bears and Lions. The holiday ends with a game between the Bills and Saints. Who will win on Thursday to get closer to the playoffs?

Jump to a match.

BUF-NO, CHI-DET, LV-DAL, and BUF-NO are all part of the same entity.

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The history of Thanksgiving in football.

John Madden's first turducken.

Every team has a memorable Thanksgiving.

The Bears are 0-7 at the Lions.

The time is 12:30 p.m. Fox

Matchup rating:

The spread is CHI - 3.5.

The Lions will be the 13th team in NFL history to enter a Thanksgiving game with a winless record, and they're still in search of their first victory of the season. Detroit will look to feed the hot hand, with D'Andre Swift leading all running backs in reception and receiving yards. Swift has 975 scrimmage yards, which is fifth among all running backs. Can the Bears find a way to slow him down?

The Bears will snap their five-game losing streak with a three- touchdown performance by the quarterback. The experience of the quarterback and his ability to get the job done against inferior teams make him a good choice to handle a rib injury to Justin Fields. Fields is still the starting quarterback for Chicago, but look for the other guy to light it up.

The Bears had the highest blitz rate by a team in a game this season and the highest rate by a team in any game since 2006 in their victory over the Ravens last week.

Bears and Lions have injuries.

With Allen Robinson II out last week, the Chicago receiver saw 16 targets and ranks in the top 20 in air yards this season, ahead of elite deep-ball options such as Mike Williams. See the Week 12 rankings.

Seven of the past eight Detroit games have gone under the total. Read more.

Bears 24, Lions 17.

Woodyard's pick was Lions 21, Bears 20.

The prediction was 64.0% by an average of 4.8 points.

In 1997, Barry Sanders ran for 167 yards and three touchdown in a 55-20 win for the Lions against the Bears. Read more.

Nagy says he's focused on the Lions, not his job status.

The Raiders are at the Cowboys.

4:30 p.m. CBS

Matchup rating:

The spread was DAL - 7.5.

Can the Cowboys handle the defense from the West? They scored at least 20 points in each of the three games. Denver and Kansas City were physical with the Cowboys on the perimeter, which helped them generate pressure against an offensive line that did not have left tackle Tyron Smith. The Las Vegas defense is tied for 26th in points allowed and Smith is expected to play against the Raiders. The Cowboys' offense has to answer the call, even though they don't have Amari Cooper and possibly CeeDee Lamb.

The Raiders' red zone issues will force Las Vegas to use backup quarterback Marcus Mariota more than the occasional third-and- short and fourth-and- short situations. Carr is more mobile than Mariota. In the past three games, the Cowboys have gotten 7.5 sacks from Parsons and 4.5 sacks from Carr. The Raiders need a spark.

Since he made his debut in 2015, Raiders tight endDarren Waller has 12 career 100 yard games, the third most by any tight end.

The Cowboys and Raiders have injuries.

In his past five games, the Cowboys running back has been held out of the end zone in four of them and has not had a carry over 11 yards in four of them. See the Week 12 rankings.


Stephania Bell and Matthew Berry are looking at the Cowboys' wide receiver situation.

Dallas is 1-9 against the spread in its past 10 Thanksgiving games. Read more.

Cowboys 27, Raiders 16.

Cowboys 26, Raiders 19.

DAL, 75.0%, by an average of 9.1 points.

In 1993, Leon Lett tried to recover a blocked field goal from the Dolphins. The ball was recovered by Miami at the 2-yard line. Pete Stoyanovich kicked a field goal to win the game for the Dolphins. Read more.

Matchup must-reads: Football lifer Bisaccia's journey to becoming the Raiders' interim coach. No longer playing an electronic game, Cowboys' player.

The Bills are at the Saints.

8:20 p.m. NBC

Matchup rating:

The spread was BUF -5.5.

These two teams are in dire need of bounce-back performances, and there is not a better place to watch them. The Saints have lost three in a row for the first time since 2016 and need to get their running back and offensive tackles back from injury as soon as possible. Buffalo has lost two of its past three and fell out of first place in the AFC East, while Bills quarterback Josh Allen has battled turnovers.

The Saints quarterback will throw at least two picks and complete less than half of his passes. He threw two picks in the loss to the Eagles, but is still completing his passes. The Bills' defense has 15 picks on the season, which is tied for the second most in the league. Buffalo has allowed opposing passers to complete less than half of their passes. The Bills' top pass defense might be set up for success by injuries to the Saints and other players.

Our experts make game picks.

The PickCenter is part of the ESPN Chalk.

There is more coverage of the NFL.

The Bills entered Week 11 allowing the lowest points per game in the league and giving up 41 to the Colts. The Saints were the top ranked run defense in the country before giving up a lot to the Eagles. The defense will bounce back in Week 12.

The Bills and Saints have injuries.

The Bills receiver has scored five times in the past five games after scoring just once in the first five. Over the final eight weeks of last season, he was a top tier player and appears to be rounding into form at the right time. See the Week 12 rankings.

New Orleans is perfect in Thanksgiving games under Sean Payton, with a perfect record of three wins and two losses. Read more.

Getzenberg's pick was the Bills.

Triplett's pick was the Bills.

The BUF, 61.7%, is predicted by the FPI.

The Saints won the NFC South title on Thanksgiving in 2019. In New Orleans' 26-18 victory, backup quarterback Taysom Hill scored two touchdown and blocked a punt. Read more.

The Bills have little room left for error after the disappointing loss to the Colts. The Saints' playoff hopes are in danger heading into the Thanksgiving game with the Bills. The Saints will have a tight end miss 3-6 weeks with a knee injury.

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