Antetokounmpo had 12 points, eight rebound and nine assists.
The Milwaukee Bucks recorded the largest half-time lead in their history as they defeated the Magic 123-92.
Seven players finished with double figures, as the Bucks led by 41 points at the half.
Jrue Holiday led with 18 points, six rebound and four assists, while reserve Pat Connaughton landed five three-pointers as he added 17 points.
It was the ninth consecutive win for the Bucks over the Magic.
The five-time NBA All-Star scored 12 points with eight rebound and nine assists.
Without Cole Anthony, the Magic have lost six of their last seven games.
A moment of silence was held prior to Monday's game for the victims of Sunday's Christmas parade crash which happened 20 miles west of Milwaukee.
Five people were killed and many more were injured when a driver crashed into a crowd.
Kevin Durant scored 27 points as the Brooklyn Nets beat the Cleveland Cavaliers.
The San Antonio Spurs were defeated by the Phoenix Suns 115-111.
The Suns' winning streak is their longest since the 2006-07 season.
The Los Angeles Kings fell to their eighth defeat in nine games as the Philadelphia 76ers defeated them 102-94.
The Charlotte Hornets, Boston Celtics, Atlanta Hawks, Indiana Pacers, and Minnesota Timberwolves all won.
