In May, he beat Shane Mosley Jr to move his professional record to 19-1.
After 18 months of fights falling off and big names slipping by the wayside, the world's best fighter has his chance at world honours.
In the early hours of Saturday, the Irish boxing star is set to make his way to the ring to challenge the WBO world title holder.
This will be the first time that Quigley has challenged for a world title. This weekend could prove to be a career defining fight for the 30-year-old, who hasn't had that fight yet as a professional.
"I've worked my way to this point and I have one more step to go, and that's to become a world champion," he said.
This fight will be a challenge for the Donegal man against an opponent who believes he is one of the world's most avoided fighters.
If he beats Quigley, Andrade would like to fight Alvarez.
A lot of the experience that Andrade brings into the ring comes from being an Olympian and a former world amateur champion.
He knows the magnitude of the task that is in front of him, but he believes he has the tools to dethrone the man known as 'Boo boo'.
I'm very confident. This is going to be a little bit different for me, I have been the favourite going into every fight I've fought, but I think in a good way. There's going to be no pressure on me, it's all going to be on Andrade.
He's the world champion, he's the perfect fighter, it's in his hometown. I'm going in there as an outsider, but I believe that I can get in there and win the world title on November 19th.
I don't let boxing define me.
One thing that could be helpful for Quigley is the fact that he has an ally in Andy Lee.
The Ballybofey fighter, who has 19 wins and one defeat from his 20-fight pro career to date, believes that having Lee in his corner on Friday could be pivotal, and the experience he has will be priceless come fight time.
He said that you can't buy that kind of experience. He's done what I want to do in my career and life.
"This is the belt that Andy once held, the WBO middleweight title, so it will be coming back to Ireland, it'll be coming back to the same stable and coming back to Andy as well."
Quigley wants to bring the world title back to Ireland and feels a huge sense of pride.
He wants to become the next world champion for Ireland.
I'm privileged and honored to represent Ireland and my county in this fight. I'll go in there and do them proud, and I have no doubts that I can bring that world title back to Donegal. I want to bring the world title back to Ireland.
It is unsurprising that boxing remains a cornerstone of Quigley's life, but the former European amateur champion likes to detach his life from his career.
Winning this fight and becoming world champion would be career defining for him, but he doesn't let boxing control his life outside of the ring.
Winning this fight will change my life in a career sense, but I don't let boxing define me and define my life and my happiness," he said.
I can assure you that becoming world champion will make me a lot happier.
It may well be one of the best wins in Irish boxing history, against one of the most avoided and highly regarded men in boxing circles, if Quigley wins this weekend.
