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Steve Clarke's Scotland is aiming for a play-off place, while Rob Page's Wales are still in the mix to win their group. Gareth Southgate's England needs four points from two games in order to qualify automatically
England is looking to confirm their World Cup spot this month. Wales and Scotland are hoping to secure play-off slots.
The last two rounds of European qualifying will begin on Thursday. Germany and Denmark are the only countries that have booked their places in Qatar.
Each group's winners are automatically selected, and the 10 runners up join two Nations League teams in play-offs where three additional places are available.
Group I - England
England v Albania (12 November, 19:45 GMT), San Marino against England (15 November, 19:45 GMT).
England will likely have to wait until their last game to secure their place in Qatar 2022.
They might qualify if they beat Albania on Friday, but they would need to lose to second-placed Poland in order to defeat Andorra. (If Poland loses, an England draw is sufficient.
Realistically, Gareth Southgate's team needs four points from the Albania match and then San Marino away three day later.
In the fight for the play-off spot, Poland is two points ahead of Albania.
Group F – Scotland
Moldova v Scotland (12 November, 17:00 GMT), Scotland against Denmark (15 November, 19:45 GMT).
To secure a place in the play-offs, Scotland must beat Moldova on Friday. They will not be able to catch the leaders Denmark who have secured the only automatic qualification spot.
Even if they lose, the Scots can still win - provided that they match Israel's Austrian result.
They may have to defeat Denmark in the final match if they lose.
Group E - Wales
Wales v Belarus (13 November, 19:45 GMT), Wales against Belgium (16 November, 19:45 GMT).
Wales will be guaranteed a place in the play-offs if they win four points from their home games against Belarus and Belgium.
They could theoretically qualify for automatic qualification - they are five point behind Belgium with two games left - but they would need to lose to Estonia and Rob Page's men at Cardiff.
If Wales defeats Belarus and Belgium loses to Belgium, and Estonia beats the Czech Republic in their last game, the goal difference would determine the play-off spot. Current results show that the Czechs are two ahead in this metric.
Even if Wales finishes outside the top 2, they will likely qualify for the play offs regardless of their Nations League group.
Wales will play in the play-offs if either Spain or France finishes in the top 2 of their qualifying groups.
Group C - Northern Ireland
Northern Ireland v Lithuania (12 November, 19:45 GMT), Northern Ireland against Italy (15 November, 19:45 GMT).
Northern Ireland is not in contention for Qatar 2022.
Italy and Switzerland are confirmed to be the top two countries - the Azzurri are just above the Swiss in goal difference going into Friday's game.
The final round of the games is when all decisions are made.
Group A
Portugal and Serbia will be guaranteed the top spot. Serbia is top by one point, but Portugal has a game in their favor.
Their match in Sunday's final game will determine who qualifies for the play-offs.
The Republic of Ireland, currently below Luxembourg where they play on Sunday, will finish third or forth.
Group B
Both Spain and Sweden have their fates in their hands. They know that two wins will get them to the World Cup. Sunday's final is likely to be winner takes all.
Spain will be qualified if they beat Greece or Sweden.
Sweden is currently the leader of the group, and they only need four points from games against Georgia and Spain.
They might even be able to qualify for the finals if Spain and Georgia do not beat Greece.
Group D
France must beat Kazakhstan in order to secure their place in Qatar. If Bosnia-Herzegovina draws with Finland, a point would suffice.
Les Bleus could lose to Finland if they lose. Ukraine is currently in second place, but they only have one remaining game.
In practice, Ukraine and Finland are likely to be competing for the playoff spot.
Group G
Both Norway and the Netherlands have their World Cup qualification fates in their hands. They will meet in Tuesday's group final.
If they beat Latvia and Montenegro, the Netherlands - the top group - could qualify for Saturday.
However, if Norway wins Latvia and then the Netherlands they will go to Qatar. Turkey is still in contention.
Group H
Russia and Croatia hold the top spots, and their match on Sunday could determine who gets the automatic spot.
Russia could qualify for the World Cup if they defeat Cyprus and Croatia, dropping points against Malta.
Group J
Germany has already been selected as the group winner.
Romania has the advantage in the play-off race. They are one point ahead of Armenia and North Macedonia, while the games against the bottom two are left.
But, nothing can be resolved in the first round.