SANTA CLARA (Calif.) -- The Arizona Cardinals will not have quarterback Kyler Murray or wide receiver DeAndre Holmes against the San Francisco 49ers Sunday.
The inactivity of both players was reported to the Levi's Stadium officials approximately 90 minutes prior to kickoff.
This will be Murray's first missed game in three years and Hopkins' third missed game in nine years.
Murray will be sidelined so Colt McCoy will take the quarterback position.
Murray still has a left ankle injury that he sustained in the Cardinals' defeat to the Green Bay Packers Oct. 28. Hopkins also sustained a hamstring injury during that game and is still dealing with it.
They were neither practiced this week.
Coach Kliff Kingsbury stated last week that Murray was playing well despite not practicing. However, the plan was for Murray to be evaluated on the field on Sunday morning before making any decision.
Arizona is 7-1 and suffered its first loss against the Packers.