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Raphael Varane fell holding his leg. Dayot Upamecano replaced him in the 43rd minute of Sunday's Nations League final.
Raphael Varane, Manchester United's defender, has been placed on "a few weeks" due to a groin injury sustained while on international duty.
During Sunday's Nations League final win against Spain, the France international was injured.
After signing from Real Madrid in August, the 28-year old has played six United games this season.
Red Devils boss Ole Gunnar Solskjaer has already lost defender Harry Maguire due to a calf injury.
United stated in a statement that Raphael Varane suffered a groin muscle injury during the Nations League final. He has begun rehabilitation at the club.
"He will be back in a few weeks."
United will be next in action Saturday, when they travel to Leicester City for the Premier League.
Solskjaer's team also has games against Liverpool, Tottenham, Manchester City, and Atalanta in Champions League.