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Thomas Muller was in Germany for more than two years under Joachim Low, before the Euro 2020 recall.
Thomas Muller scored the first goal in a competitive match for Germany since 2017, when they beat Romania in World Cup qualifying.
After nutmegging Antonio Rudiger, Ianis Hagi of Rangers gave Romania a surprise lead before poking past Marc-Andre Ter Stegen.
Serge Gnabry used a German leveller to drill from outside the box.
Substitute Muller won the final victory at the back post, after Leon Goretzka had flicked in a corner.
Germany could be in the World Cup if they win against Armenia and North Macedonia, but not Romania.
It was the second consecutive time Germany won a home match after being trailing at halftime. The other was a 4-1 victory over Estonia in August 1937.
Muller's final competitive goal was against Azerbaijan in February 2017, after he had been exiled for two year under Joachim Low.
Germany has won all four games since Hansi Flick, former Bayern Munich boss, was replaced by Low following Euro 2020.
With three games remaining, the Group J leaders are six points ahead of North Macedonia who beat Liechtenstein by 4-0.
Davy Klaassen's goal from Memphis Depay's corner helped the Netherlands defeat Latvia 1-0 in Group A.
They are two points ahead of Norway and four ahead of Turkey. These two sides drew 1-1 at Istanbul.
With a 3-0 win over Cyprus, Croatia is now ahead of Russia in Group H goal difference. Russia defeated Slovakia 1-0 at home due to Milan Skriniar's own goal.