![San Francisco 49ers rookie QB Trey Lance replaces injured Jimmy Garoppolo in loss](https://a2.espncdn.com/combiner/i?img=%2Fphoto%2F2021%2F1003%2Fr917969_1296x729_16%2D9.jpg)
SANTA CLARA (Calif.) -- Trey Lance, a rookie quarterback for the San Francisco 49ers, took over for Jimmy Garoppolo in the second half of Sunday’s 28-21 loss against the Seattle Seahawks.
The Niners announced that Garoppolo had suffered a right calf injury just moments after Lance took his first snap of the third period. Garoppolo was initially listed as questionable but he did not return to play. Garoppolo briefly wore a wrap around his calf, but he removed it quickly and was seen walking with a slight limp.
Garoppolo was 14-of-24 for 165 yards, with a touchdown pass and an interception. The Niners took a 7-0 lead in the first 30 minutes. They entered the second half tied at 7. Garoppolo was 6-of-6 on 70 yards with a touchdown and the first drive, but he went 8-of-17 on 95 yards and an intercept the rest.
Lance chatted with Rich Scangarello and Kyle Shanahan when the Niners returned to the field to begin the third quarter. Before Lance took to the field, Garoppolo gave Lance a quick hug.
Lance was 19-of-18 and rushed for 157 yards with two touchdowns. On seven carries, he added 41 yards to the ground.