Colts place All-Pro guard Quenton Nelson on IR as starting streak ends

Marcus Spears explains how Jacoby Brissett will lead the Dolphins to victory against the Colts. (1:16).
Quenton Nelson, Indianapolis Colts' guard, will miss at least three weeks of his NFL career after being placed on injured reserve Saturday for a high right ankle strain.

Nelson was already set to miss his first NFL game as the No. He was the 6th pick in the 2018 draft. Before this week, he had played in 51 games and three playoff contests.

In the first half of Colts' Week 3-loss at Tennessee Titans, he sustained an ankle injury.

The Colts' loss of Nelson, an All Pro in his first three seasons, is a major blow to their already weak offensive line. They have surrendered eight sacks and 31 quarterback hits during the first three weeks.

According to ESPN Stats & Information, Nelson's 75.5% rate of run-block is the highest among NFL guards. His 95% pass win rate ranks third among all guards during the same time period.

Chris Reed will likely start at left guard against the Dolphins for the Colts.

Frank Reich, coach of Nelson, said that Nelson was "an elite leader, and not just a elite player." We'll get the energy up."

The Colts are trying to avoid a 0-4 start, which is their first since 2011. They previously excluded starting right tackle BradenSmith (foot/thumb), pass rusher KwityPaye (hamstring), cornerback Rock Yasin (ankle), and safety Khari Williams (ankle/groin).

Indianapolis promoted quarterback Brett Hundley to the active roster and safety Ibraheim Camp to the active roster for Sunday’s game.

This report used information from ESPN's Mike Wells.