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Wales captain Gareth Bale scored 36 goals in his 99 appearances for his nation.
Real Madrid forward Gareth Bale will be absent due to injury when Robert Page names his World Cup qualifying squad against Estonia and Czech Republic.
Real has lost five of their last five games due to Bale's injury, which Carlo Ancelotti, Real's manager, described as "important".
The 32-year old would have won his 100th match against the Czechs in Prague on Friday 8 October.
Page will announce his squad Tuesday and Aaron Ramsey is expected back.
Former midfielder for Arsenal and Cardiff City, 30-year-old, was substituted by Juventus in Sunday's 3-2 Serie A victory over Sampdoria. He had missed Wales' three September games due to a thigh injury.
After a Finland friendly with a score of 0-0, Page's team had two World Cup qualifiers where Bale was a full participant.
The all-time leading goal scorer in Wales scored a hat trick deep into extra time to win a dramatic 3-2 victory over Belarus in Russia.
He was disappointed with the team's draw in Cardiff to Estonia group minnows three days later.
Bale has been out of action since then, having reportedly suffered a hamstring injury during Madrid training. Real boss Ancelotti later stated that it was difficult to predict how long he would be away from the team.
Wales is third in Group E qualifying for 2022 Qatar World Cup. They are level on points with Czechs, but nine points behind leaders Belgium.
The Estonians will be their away qualifier on Monday, 11th October.