Nano-scale Borate Bioactive glass. Credit: MA KunScientists have recently created nano-scale borate active glass (NanoHCA@BG) using a steady-state magnetic field experiment device. This can reduce biological toxicity and biocompatibility of borate bioglass as well as promote skin repair with borate bioglass.Prof. Wang Junfeng, from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, collaborated with Prof. Zhang Teng, Fuzhou University, to conduct this study. He said that "it is expected it will become the next generation of wound repair dressings for skin." Chemical Engineering Journal published related research.Borate bioglass is made with boron (B) as the network matrix. It is a glass with excellent dopability and degradation, which has great potential for skin tissue repair. It does however release a lot of alkaline ions. The explosive release of these ions can alter the acid-base environment in the tissue surrounding the glass material and inhibit cell proliferation.Additionally, the surface area of the micron-sized borate glass in contact with the wound tissues is very small. The ions on the glass are not conducive for the deposition collagen so scarring can easily form at the wound after it heals. It is urgent to create a nano-scale borate glass with excellent biological performance and no biological toxicity.The researchers used a mobile phase to treat micron-sized borate bioglass in vitro. The researchers obtained Nano-scale (50nm), borate bioglass (NanoHCA@BG), which was then covered with an amorphous HCA (HCA).The ions (PO432- and CO322-) from the mobile phase were formed on the glass's surface to form the HCA coating. This effectively inhibted the rapid release of calcium and boron in the remaining glass, and thus reduced its biological toxicity to cells.HCA, an important inorganic element in bones, is biocompatible and can be used to accelerate collagen synthesis in tissues.In vitro and cell experiments as well as animal experiments have shown that nano-HCA@BG slow released boron calcium and other elements can significantly accelerate wound cell migration.The amorphous HCA coating on the glass surface reduces glass's rapid release and promotes collagen deposition in the wound. This promotes faster healing.Continue reading Effects of composites containing bioactive glass on demineralized tinMore information: Ruiguo Chen and al, Nanosized HCA coated borate bioactive glasses with improved wound healing effects in rodent models, Chemical Engineering Journal (2021). Ruiguo Chen and colleagues, Nanosized HCA coated borate bioactive glasses with better wound healing effects for rodent models, (2021). DOI: 10.1016/j.cej.2021.130299Hefei Institutes of Physical Science and Chinese Academy of Sciences provide this service.
