Duke vs. Ohio State, Michigan vs. UNC Top 2021 Big Ten/ACC Challenge CBB Matchups

Leon Halip/Getty ImagesMike Krzyzewski will be coaching the Duke Blue Devils against the Ohio State Buckeyes in the final Big Ten/ACC matchup of his coaching career.The interleague competition this year features a number of high-profile matchups across three days. Michigan State hosts Louisville, Syracuse hosts Indiana and North Carolina hosts Michigan.The series will be held from Nov. 29 through Dec. 1. For its second consecutive win, the Big Ten took home the challenge last year 7-5.Despite being 4-3 against Ohio State, Duke has not faced the Buckeyes during the regular season since 2012. North Carolina is playing its first season in the new Hubert Davis era. It has lost to Michigan at Battle 4 Atlantis and is 4-4 against Michigan.The sixth meeting between two blue bloods from Indiana and Syracuse will be a rematch of the previous five meetings. The Orange won the last meeting in 2013.Many schools will be facing off in the Big Ten/ACC Challenge history. The ACC is the overall leader in conference series, with 12-7-3 overall record and 138-113 individual game wins.The schedule for this year will likely include some ranked matchups.These schools were included in ESPN's preseason rankings on June 1: No. 5 Ohio State, Number. 6 Purdue is No. 8 Michigan, No. 12 Maryland, No. 13 Duke, No. 16 Virginia Tech, Number. 19 Florida State, Number. 20 North Carolina, Number. Virginia and No. 23 Virginia and No.These rankings have given us a list of the top ACC/Big Ten matchups.No. 13 Duke at No. 13 Duke at No.No. 19 Florida State at Number. 6 PurdueNo. 8 Michigan at No. 20 North CarolinaNo. 16 Virginia Tech at Number. 12 MarylandThere are many things that can take place between June and November. However, the current schedule is expected to include at least a few ranked matches. The Big Ten/ACC Challenge is always entertaining.