A first-half goal by Ousmane Dembele gave Barcelona a first-half lead and they held on to beat Atleti Madrid.
Dembele hit a post in the second half after scoring his first goal of the game.
Ronald Araujo was the one who cleared the line forAntoine Griezmann's attempt to tie the game.
Both sides finished with 10 men after two of them were ejected for fighting.
The two former Manchester City players were shown red cards for fighting after the ball ended up on the ground.
Real Madrid's defeat at the hands of Villarreal on Saturday opened up a cushion at the top of the league.
The most consecutive games in charge of a single club in Spain's top flight was held by Diego Simeone.
The Argentine saw his side fall to a fifth loss in 16 games and his hopes of winning the title are gone.
Dembele's goal was the culmination of a slick team move as Pedri's burst of acceleration fed the France winger to finish into the bottom corner.
Pedri's lofted effort from Jose Gimenez's blind backpass was clawed out by Jan Oblak.
Atleti were chasing the game in the second half as they looked to get something out of it, but their rising drive was tipped over the bar by Ter Stegen.
A goal that was ruled out for offside in the second period was followed by a fracas in the final few minutes that resulted in the pair being dismissed.
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