The Bills made an emotional show of support for Hamlin in their first game since he suffered a cardiac arrest.
After a stirring build-up to the game, the Bills running back returned the opening kick-off for a touchdown.
Hamlin was watching from his bed.
The Bills have patches of Hamlin on their jerseys.
Fans held up banners with messages of support while the players arrived wearing T-shirts and caps with his name and number on them.
There was a message on the big screens at the stadium.
Hamlin is still in a critical condition despite the Bills saying on Saturday that he is making progress.
Hamlin wanted to run out that tunnel with his brothers on game day.
Today, God is using me in different ways. Today, tell someone you love them.
Hamlin was resuscitated by the medical staff of the Bills.
There was a rapturous round of applause for Hamlin prior to the US national anthem being sung.
Josh Allen put his hands on his helmet in disbelief after Hines returned the ball 96 yards for a stunning opener.
Prior to leading his team onto the field, Allen tapped the number three patch on his jersey and told his team-mates not to play for the name on the back.
We play for that number on our front as well.
The commissioner wore a blue cap with the number 3 on it.
One of the Bills' team colors is painted on the '3' on the 30 yard line.
The number three was painted on the field and the players wore 'Love for Damar 3' T-shirts during their warm-ups as a show of support for the player.
The Bills quoted Hamlin's doctors as saying that he has been able to communicate with his family and care team after his breathing tube was removed.
The Bills game was canceled by the National Football League.
The change to the play-off structure was approved by the owners because the outcome of the game would affect seedings.
After the final round of games take place this weekend, the playoffs will be determined by the team's winning percentage over their 16 games.
If the home team would have been settled by the canceled game, the game would have been played at a neutral site.
It will be played at a neutral venue if the Bills beat the Pats and the Chiefs beat the Broncos in the playoffs.
If the Pats beat the Bills, they'll get a play-off spot, but a loss could open the door for the Dolphins or theSteelers.