Tennessee will start Joshua Dobbs at quarterback against the Jacksonville Jaguars on Saturday, according to the coach.
The game takes place in Jacksonville. The division will be won by ABC.
TheTitans lost their sixth game in a row on Thursday night against the Dallas Cowboys.
The quarterback threw for 232 yards and a touchdown in the 27-13 loss.
The rookies have not been effective in three starts.
In his three starts in place of Tannehill, the third-round pick has failed to throw for 100 yards or a touchdown. TheTitans are 1-2 in his starts, despite him completing less than half of his passes. He has scored a touchdown.
According to sources, Ryan Tannehill will be out for the rest of the season and possibly the playoffs after having surgery on his ankle. Tannehill will have to sit out at least three games before he is able to return.
The Jags have won four in a row.
Turron Davenport was a contributor.