The film earned an estimated $134 million in its opening weekend, making it one of the most expensive movies of all time to make.
According to The Hollywood Reporter, the film brought in $301 million in ticket sales around the world.
The sequel was expected to make up to $170 million, but it was later estimated to make between $130 million and $150 million.
"Doctor Strange in the Multiverse of Madness" leads this year's box office opening charts with $187.4 million after tying "The Batman" in its March debut.
The movie brought in nearly double the amount of money earned by the first movie in the series. It was the highest grossing film of all time with nearly $3 billion in ticket sales.
The way of water raked in $53 million on its opening day, which may not be enough.