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ImageA nurse prepares vaccine boosters at a Covid center in Washington D.C.
A nurse prepares vaccine boosters at a Covid center in Washington D.C.Credit...Kenny Holston for The New York Times
A nurse prepares vaccine boosters at a Covid center in Washington D.C.

The last one for the year is today. The year started as the surge in the Omicron variant in the U.S. was nearing its peak. The seven-day average of deaths peaked at 2,669.

There will be an increase in Covid cases as the year ends. The seven day average of deaths is up 65 percent. Several cities and counties, including New York City and Los Angeles, have advised people to mask up because of the flu and R.S.V.

Some people have never had Covid this season.

Scientists believe that people who are naturally immune and whose genetics hold clues for treatment are the true "never coviders."

Jonathan Wolfe spoke with a colleague about how scientists are looking for them.

Is this really true?

It is probably true. There are people who are naturally resistant to certain Viruses. The most striking example I can think of is H.I.V., where some people are resistant to the virus due to a genetic abnormality. The very few people that have been cured of H.I.V. have been able to attribute that to that.

People who have never gotten Covid are wondering what's going on.

We don't know if it's true.

Genetics can be used to be resistant to a Viruses. The coronaviruses need an ACE2receptor on a cell in order to get to it. The virus can't get into your cells if you have a deficiency in that particularreceptor. It's likely to be very rare.

Genetics play a part in how sick people are. The innate immune system is like the first responders part of your immune system and can be a bit generic. There are more specific reactions that occur in an infection.

People who have a certain type of first responders tend to be very sick. The flip side is also likely to be true, as some people may have certain genetic quirks that prevent them from getting sick.

Is it possible that they could just be normal?

People who are not showing signs of disease are still getting infections. They don't have any symptoms of the virus in their bodies. That is very different from what we are talking about here, which is someone who doesn't get infectious at all. It has been hard for researchers to understand the difference between the two groups because so many people have been exposed.

Do you mean what you say?

Many people thought they were immune to the disease. I have had friends tell me that, but I haven't received it yet. I should be studied by scientists. People who didn't get Covid were studied by some researchers. Omicron came along and caused a lot of problems. Scientists had to start over, and they were very frustrated. Those people were not coviders. The studies will be based on people who aren't infectious.

Scientists are studying health care workers and caregivers who were exposed to high levels of exposure but didn't get sick. The idea is that we can figure out treatments for infections if we know what causes someone to not get sick.

There are many people who are not coviders.

There are a lot of unknowns. We don't know if all the people who say they haven't gotten it yet have or haven't had it. We don't know if they've been so careful that the virus hasn't had a chance to get to them.

The vaccines gave some immunity against infections, which caused things to get complicated. The number of people who are completely immune to the virus is not very large.

Is it possible that I have never been exposed to an infectious disease?

You're lucky if you haven't gotten it yet, either because you're genetically lucky or you've dodged the virus. I wouldn't assume that you are resistant to the wind. It is very unlikely that you are naturally immune. It might be that you haven't met the right variant yet.

We asked you how you think you've avoided Covid so far, and received over 10,000 responses.

I took care of a friend with cancer and avoided everyone because I wanted him to be safe. I started seeing new people again after he died, but I haven't caught on yet. I either have a Covid guardian angel or I am immune.

It's a healthy constitution. Early precautions, masking, vaccines, boosters, working from home and luck were some of the things that rarely resulted in a cold or flu before the outbreak. We gave up our masks two and a half years ago because we didn't have a sniffle. It's likely that I will jinx myself as I type.

My husband and I haven't caught Covid due to luck. We don't have children. We have a small group of friends who share the same views on how to navigate the Pandemic. We were able to live in Wyoming at the start of the Pandemic because it isn't densely populated. In Japan, we have become embedded in a culture that emphasizes public health and welfare over individualism. The mask-wearing is normal here, making it easier for us to continue the habits that have kept us safe and healthy.

I don't know. It was stupid luck. When my husband had Providence, I was in the basement. He has suffered from long Covid and it has changed his life.

I knew I had to do everything I could to not get sick from my immune system. In the first year of the Pandemic, I was confined to my home. I used to work with an FFP2 mask, never took the bus or train, was never in the supermarket without one, and avoided places with a high risk of infections. I have all the immunizations. I wear a mask in public places. They tested themselves before they came to see me. I am very thankful for that.

I was sent home early in the Pandemic because I had just finished treatment for cancer. I work from home for two years now. The vaccine was available to me as soon as possible. The bivalent vaccine is one of the boosters I have gotten. The mask protocol is to check your surroundings. There is a ceiling. The person is wearing a mask. There is a crowd. The person is wearing a mask. No, neither? It's time to take it off. I think I have been exposed but was not diagnosed with an allergy.

TheTripledemic is what it is.

There is a coronaviruses.

There is a flu.

There is an outbreak of the E. coli disease.

  • The Ugandan authorities were reluctant to impose restrictions because of the trauma from the Covid lockdown. It's a decision that hurts the country.

Thank you for reading On January 4, we will be back.

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